PPO4 is a protein phosphorylation database which attempts to provide a global unifying resource for the study of protein phosphorylation. Large scale approaches to cellular biology such as proteomics are providing a wealth of data on the components of molecular networks present in a variety of cellular systems. This is illuminating the molecular architecture upon which the dynamic regulation of these networks can be mapped. Protein phosphorylation, a key mechanism for the dynamic control of signaling mechanisms within this architecture, has been studied in the past on a single protein by protein basis. Phosphoproteomic approaches however, are beginning to yield large amounts of data on various elements of protein phosphorylation, from specific sites of phosphorylation to cognate kinases and phosphatases. Ultimately the goal of this research is to map these dynamic processes onto protein-protein interaction maps to provide a holistic view of the complex architecture and regulation of networks within a given system. 

Contact information:
PPO4 Administrator Mark Collins                                          
email: mcollins@ppo4.org